Anti-angiogenic effects of pterogynidine alkaloid isolated from Alchornea glandulosa
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چکیده
منابع مشابه
Anti-angiogenic effects of pterogynidine alkaloid isolated from Alchornea glandulosa
BACKGROUND Angiogenesis, a complex multistep process that comprehends proliferation, migration and anastomosis of endothelial cells (EC), has a major role in the development of pathologic conditions such as inflammatory diseases, tumor growth and metastasis. Brazilian flora, the most diverse in the world, is an interesting spot to prospect for new chemical leads, being an important source of ne...
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Alchornea glandulosa has traditionally been used in Brazilian folk medicine for the treatment of immune-inflammatory diseases and as an antiulcer agent to heal gastric ulcer and gastritis. Angiogenesis is a complex multistep process that consists of proliferation, migration, and anastomosis of endothelial cells and has a major role in the development of pathologic conditions, such as inflammato...
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In the present study, anti-anaphylactic, anti-inflammatory and membrane stabilizing properties of a lupine alkaloid plumerianine (compound 1), isolated from the root bark of Plumeria acutifolia Poir were investigated in animal models. The anti-anaphylactic activity of compound 1 (10, 25 and 50 mg/Kg) was studied by using models such as passive cutaneous anaphylaxis, passive paw anaphylaxis and ...
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ژورنال
عنوان ژورنال: BMC Complementary and Alternative Medicine
سال: 2009
ISSN: 1472-6882
DOI: 10.1186/1472-6882-9-15